Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of nucleocapsid total immunoglobulin, underscoring the need to account for seroreversion in seroepidemiologic studies.

中文翻译：

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纵向 SARS-CoV-2 核衣壳抗体动力学、血清逆转以及对血清流行病学研究的意义

鉴于在生产冠状病毒疾病疫苗中广泛使用尖峰抗体，SARS-CoV-2 核衣壳抗体越来越多地用于指示血清学调查中的先前感染。然而，纵向动力学和血清逆转定义不清。我们发现核衣壳总免疫球蛋白的大量血清逆转，强调了在血清流行病学研究中考虑血清逆转的必要性。