Steroidal mineralocorticoid receptor antagonists (MRAs) form a cornerstone of the management of heart failure (HF), but little is known about the long-term effects of MRA therapy on kidney function. We evaluated acute and chronic estimated glomerular function (eGFR) slopes in the two largest completed trials testing steroidal MRAs in chronic HF.

中文翻译：

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甾体盐皮质激素受体拮抗剂对慢性心力衰竭患者急性和慢性估计肾小球滤过率斜率的影响

类固醇盐皮质激素受体拮抗剂 (MRA) 是治疗心力衰竭 (HF) 的基石，但人们对 MRA 治疗对肾功能的长期影响知之甚少。我们在两个最大的已完成试验中评估了急性和慢性估计肾小球功能 (eGFR) 斜率，这些试验测试了慢性 HF 中的类固醇 MRA。