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Compound Interaction Screen on a Photoactivatable Cellulose Membrane (CISCM) Identifies Drug Targets
ChemMedChem ( IF 3.6 ) Pub Date : 2022-07-22 , DOI: 10.1002/cmdc.202200346
F Teresa I Melder 1 , Peter Lindemann 2 , Alexander Welle 3 , Vanessa Trouillet 4 , Stefan Heißler 3 , Marc Nazaré 2 , Matthias Selbach 1
Affiliation  

Parallel identification: We present a new compound interaction screen on a cellulose membrane (CISCM) that combines undirected photoimmobilization of compounds on cellulose with affinity purification mass spectrometry and label free quantification (LFQ) to identify the protein targets of several compounds in parallel.

中文翻译:

光活化纤维素膜 (CISCM) 上的化合物相互作用筛选可识别药物靶点

平行鉴定:我们在纤维素膜 (CISCM) 上展示了一种新的化合物相互作用筛选,它将化合物在纤维素上的无向光固定化与亲和纯化质谱和无标记定量 (LFQ) 相结合,以并行鉴定多种化合物的蛋白质靶标。
更新日期:2022-07-22
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