This research was conducted to develop a novel adsorbent based on hyperbranched polyester dendrimers for selective determination and separation of donepezil hydrochloride. In this paper, different generations of hyperbranched polyester dendrimers were grafted onto graphene oxide. New types of carboxyl-terminated hyperbranched polyesters with aromatic-aliphatic structure were synthesized using the direct esterification reaction between succinic acid and phloroglucinol in the presence of p-toluene sulfonic acid catalysts. The 5th generation of polyester dendrimers was modified by p-aminohippuric acid to enhance its adsorption capacity and improve dendrimer biocompatibility. The hyperbranched polyester dendrimers with magnetic nanoparticles were obtained through vacuum freeze-drying process and was used in a new method for the preparation of three-dimensional/ graphene oxide-grafted hyperbranched polyester dendrimers. The synthesized nanoparticles were investigated using Fourier-transform infrared spectrometry, X-ray diffraction, field-emission scanning electron microscopy equipped with energy-dispersive spectroscopy, transmission electron microscopy, Brunauer-Emmett-Teller, thermal gravimetric analysis and vibrating sample magnetometry. The effective experimental parameters were optimized. Adsorption of donepezil hydrochloride by nanoadsorbent can be best described by a Langmuir isotherm with a high correlation coefficient. The three-dimensional/ graphene oxide -grafted hyperbranched polyester dendrimers were applied for extraction of donepezil hydrochloride from biological and pharmaceutical samples through high-performance liquid chromatography-ultraviolet technique.

本研究旨在开发一种基于超支化聚酯树枝状大分子的新型吸附剂，用于选择性测定和分离盐酸多奈哌齐。在本文中，将不同代的超支化聚酯树枝状大分子接枝到氧化石墨烯上。采用琥珀酸与间苯三酚在对甲苯磺酸催化剂存在下的直接酯化反应，合成了具有芳-脂结构的新型端羧基超支化聚酯。第五代聚酯树枝状大分子通过对氨基马尿酸改性，增强其吸附能力，提高树枝状大分子的生物相容性。通过真空冷冻干燥工艺获得了具有磁性纳米粒子的超支化聚酯树枝状大分子，并用于制备三维/氧化石墨烯接枝的超支化聚酯树枝状大分子。使用傅里叶变换红外光谱、X 射线衍射、配备能量色散光谱的场发射扫描电子显微镜、透射电子显微镜、Brunauer-Emmett-Teller、热重分析和振动样品磁力测定法研究合成的纳米颗粒。优化了有效的实验参数。纳米吸附剂对盐酸多奈哌齐的吸附可以用具有高相关系数的 Langmuir 等温线来最好地描述。