Underrepresented Populations in Parkinson's Genetics Research: Current Landscape and Future Directions,Movement Disorders

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Underrepresented Populations in Parkinson's Genetics Research: Current Landscape and Future Directions
Movement Disorders ( IF 7.4 ) Pub Date : 2022-07-22 , DOI: 10.1002/mds.29126
Artur Francisco Schumacher-Schuh _{1,

2} , Andrei Bieger ₃ , Olaitan Okunoye ₄ , Kin Ying Mok _{5,

6} , Shen-Yang Lim ₇ , Soraya Bardien ₈ , Azlina Ahmad-Annuar ₉ , Bruno Lopes Santos-Lobato ₁₀ , Matheus Zschornack Strelow ₁₁ , Mohamed Salama ₁₂ , Shilpa C Rao ₁₃ , Yared Zenebe Zewde ₁₄ , Saiesha Dindayal ₁₅ , Jihan Azar ₁₂ , Lingappa Kukkle Prashanth ₁₆ , Roopa Rajan ₁₇ , Alastair J Noyce ₁₈ , Njideka Okubadejo ₁₉ , Mie Rizig ₂₀ , Suzanne Lesage ₂₁ , Ignacio Fernandez Mata ₁₃ ,

Affiliation

Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, United Kingdom.
Department of Neurodegenerative Disease and UK Dementia Research Institute, University College of London, London, United Kingdom.
Division of Life Sciences, Hong Kong University of Science and Technology, Hong Kong, China.
Division of Neurology, Department of Medicine, and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Laboratório de Neuropatologia Experimental, Universidade Federal do Pará, Belém, Brazil.
Graduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Institute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Genomic Medicine Institute, Lerner Research Institute, Genomic Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Department of Neurology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Division of Neurology, Department of Neurosciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Center for Parkinson's Disease and Movement Disorders, Manipal Hospital, Bangalore, India.
Department of Neurology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Preventive Neurology Unit, Centre for Prevention, Detection and Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.
Department of Medicine, College of Medicine, University of Lagos, Lagos State, Nigeria.
Institute of Neurology, University College of London, London, United Kingdom.
Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, CIC Neurosciences, Paris, France.

Human genetics research lacks diversity; over 80% of genome-wide association studies have been conducted on individuals of European ancestry. In addition to limiting insights regarding disease mechanisms, disproportionate representation can create disparities preventing equitable implementation of personalized medicine.

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