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Ace-ylation in the hole
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2022-07-21 , DOI: 10.1038/s41589-022-01083-7
Micah J Niphakis 1 , Benjamin F Cravatt 2
Affiliation  

Mutant-selective KRAS-targeting drugs hold great promise for the treatment of some of the most aggressive forms of cancer. Building on the breakthrough success of KRAS-G12C inhibitors, researchers have now found a way to target another mutant KRAS with serine-modifying covalent inhibitors.

中文翻译:

空穴中的乙酰化

突变选择性 KRAS 靶向药物在治疗一些最具侵袭性的癌症方面具有广阔前景。在 KRAS-G12C 抑制剂取得突破性成功的基础上,研究人员现已找到一种方法,用丝氨酸修饰共价抑制剂靶向另一种突变体 KRAS。
更新日期:2022-07-22
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