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Dual-strategy biosensing of glucose based on multifunctional CuWO4 nanoparticles
Analyst ( IF 3.6 ) Pub Date : 2022-07-22 , DOI: 10.1039/d2an01003h Yu Zhang 1 , Shuang Li 1 , Hongyuan Liu 1 , Feng Shi 2 , Juan Li 2 , Xiaoya Hu 2 , Zhanjun Yang 2
Analyst ( IF 3.6 ) Pub Date : 2022-07-22 , DOI: 10.1039/d2an01003h Yu Zhang 1 , Shuang Li 1 , Hongyuan Liu 1 , Feng Shi 2 , Juan Li 2 , Xiaoya Hu 2 , Zhanjun Yang 2
Affiliation
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In this research, dual-strategy biosensing of glucose was proposed based on multifunctional CuWO4 nanoparticles (CuWO4 NPs), which were prepared for the application of electrochemical and colorimetric sensing of glucose. CuWO4 NPs show large specific surface area and good conductivity as well as excellent peroxidase-like activity. A sensitive and selective electrochemical glucose biosensor was fabricated with the immobilization of glucose oxidase (GOx) on a CuWO4 NP modified electrode for enhancing the direct electron transfer behavior. A wide linear range of 0.005–1.8 mM with a low detection limit of 1.5 μM and a high sensitivity of 28.02 mA M−1 cm−2 were achieved by using the electrochemical biosensor. Meanwhile, a colorimetric and visual glucose biosensor was constructed based on the GOx/CuWO4 cascade nanozyme, which shows a linear range of 0.05–1.0 mM with excellent selectivity. CuWO4 NPs as a promising matrix open up a dual-strategy biosensor for sensitive and selective detection of glucose.
中文翻译：
基于多功能CuWO4纳米颗粒的葡萄糖双策略生物传感
在这项研究中，基于多功能CuWO 4纳米粒子（CuWO 4 NPs）提出了葡萄糖的双策略生物传感，该纳米粒子被制备用于葡萄糖的电化学和比色传感应用。CuWO 4 NPs表现出较大的比表面积和良好的导电性以及优异的类过氧化物酶活性。通过将葡萄糖氧化酶 (GOx) 固定在 CuWO 4 NP 修饰电极上以增强直接电子转移行为，制备了一种灵敏且选择性的电化学葡萄糖生物传感器。0.005–1.8 mM 的宽线性范围，1.5 μM 的低检测限和 28.02 mA M -1 cm -2的高灵敏度通过使用电化学生物传感器来实现。同时，基于GOx/CuWO 4级联纳米酶构建了比色视觉葡萄糖生物传感器，其线性范围为0.05-1.0 mM，具有优异的选择性。CuWO 4 NPs 作为一种有前途的基质，为葡萄糖的灵敏和选择性检测开辟了一种双策略生物传感器。
更新日期：2022-07-22
中文翻译：
基于多功能CuWO4纳米颗粒的葡萄糖双策略生物传感
在这项研究中，基于多功能CuWO 4纳米粒子（CuWO 4 NPs）提出了葡萄糖的双策略生物传感，该纳米粒子被制备用于葡萄糖的电化学和比色传感应用。CuWO 4 NPs表现出较大的比表面积和良好的导电性以及优异的类过氧化物酶活性。通过将葡萄糖氧化酶 (GOx) 固定在 CuWO 4 NP 修饰电极上以增强直接电子转移行为，制备了一种灵敏且选择性的电化学葡萄糖生物传感器。0.005–1.8 mM 的宽线性范围，1.5 μM 的低检测限和 28.02 mA M -1 cm -2的高灵敏度通过使用电化学生物传感器来实现。同时，基于GOx/CuWO 4级联纳米酶构建了比色视觉葡萄糖生物传感器，其线性范围为0.05-1.0 mM，具有优异的选择性。CuWO 4 NPs 作为一种有前途的基质，为葡萄糖的灵敏和选择性检测开辟了一种双策略生物传感器。
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