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Synthesis of a novel nucleotide unit containing cytosine analog bearing phosphodiester function and formation of silver(I)-mediated DNA duplex
Nucleosides, Nucleotides & Nucleic Acids ( IF 1.1 ) Pub Date : 2022-07-22 , DOI: 10.1080/15257770.2022.2100903 A.T.M. Zafrul Azam 1 , Itaru Okamoto 1 , Akira Ono 1
中文翻译:
含有具有磷酸二酯功能的胞嘧啶类似物的新型核苷酸单元的合成和银(I)介导的 DNA 双链体的形成
更新日期:2022-07-22
Nucleosides, Nucleotides & Nucleic Acids ( IF 1.1 ) Pub Date : 2022-07-22 , DOI: 10.1080/15257770.2022.2100903 A.T.M. Zafrul Azam 1 , Itaru Okamoto 1 , Akira Ono 1
Affiliation
Abstract
Novel modified cytosine analogs bearing phosphodiester/thiophosphodiester functionality were synthesized. The interactions between different metal ions and modified cytosine-cytosine base-pairs in DNA duplexes were investigated by UV-melting experiments. The thiophosphodiester modification binds to the Ag(I) ions strongly compared to the phosphodiester counterpart as examined in ESI-MS spectra as well.
中文翻译:
含有具有磷酸二酯功能的胞嘧啶类似物的新型核苷酸单元的合成和银(I)介导的 DNA 双链体的形成
摘要
合成了具有磷酸二酯/硫代磷酸二酯功能的新型修饰的胞嘧啶类似物。通过紫外熔解实验研究了DNA双链体中不同金属离子和修饰的胞嘧啶-胞嘧啶碱基对之间的相互作用。与磷酸二酯对应物相比,硫代磷酸二酯修饰与 Ag(I) 离子的结合力更强,这在 ESI-MS 光谱中也进行了检查。