In this issue of Cell Chemical Biology, Berton and colleagues describe a small-molecule inhibitor of the metal-dependent phosphatase PPM1A that enhances phosphorylation of the autophagy adapter p62. Inhibiting PPM1A results in enhanced clearance of Mycobacterium tuberculosis-infected macrophages, pointing to phosphatases as potential targets for host-directed therapies for tuberculosis.

中文翻译：

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标记你就是它：磷酸酶抑制剂改变了细胞内分枝杆菌的命运

在本期细胞化学生物学中，Berton 及其同事描述了一种金属依赖性磷酸酶 PPM1A 的小分子抑制剂，可增强自噬接头 p62 的磷酸化。抑制 PPM1A 可增强结核分枝杆菌感染的巨噬细胞的清除率，这表明磷酸酶是结核病宿主定向疗法的潜在靶点。