In a recent publication in Nature, Fane et al. establish WNT5A as a central, age-sensitive regulator of the dormancy-to-reactivation axis of melanoma. They show that aged fibroblasts in the lungs suppress WNT5A signaling induced at the primary tumor site to awaken dormant melanoma cells and promote the outgrowth of metastases.

中文翻译：

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老化的肺微环境唤醒黑色素瘤转移

在《自然》杂志最近发表的一篇文章中，Fane 等人。将 WNT5A 确立为黑色素瘤休眠-再激活轴的中央、年龄敏感调节因子。他们表明，肺部老化的成纤维细胞会抑制在原发性肿瘤部位诱导的 WNT5A 信号传导，从而唤醒休眠的黑色素瘤细胞并促进转移瘤的生长。