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Adsorption of Inhalation Anesthetics on Activated Carbon in Humid Atmosphere
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2022-07-21 , DOI: 10.1021/acs.jced.2c00132 Jan Hojak 1 , Christian Bläker 1 , Christoph Pasel 1 , Dieter Bathen 1, 2
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2022-07-21 , DOI: 10.1021/acs.jced.2c00132 Jan Hojak 1 , Christian Bläker 1 , Christoph Pasel 1 , Dieter Bathen 1, 2
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Halogenated ethers, especially fluranes, are commonly used as inhalation anesthetics in medical treatment of humans and animals. As they pose a health risk to clinicians and have a significant effect on global warming, separation from indoor air in hospitals is desirable. This paper presents adsorption isotherms for desflurane, isoflurane, and sevoflurane at 25 °C on activated carbon D47/3 at 1 bar under a dry and humid atmosphere. Trace level flurane concentrations between 50 and 500 ppm and relative humidities between 10 and 50% were investigated. A magnetic suspension balance and a flame ionization detector were used to determine the loading of flurane and water simultaneously. The results show that the higher the relative humidity, the lower the adsorption capacity of activated carbon. We show that coadsorption of fluranes and water is dominated by the molecular size, polarizability, and polarity. This results in limited pore accessibility of fluranes, dispersion interactions of fluranes and the carbon surface, and polar interactions of fluranes and water. From the isotherm data we derive mechanistic effects like blocking of adsorption sites by preadsorbed water, displacement of adsorbed water molecules with increasing amount of flurane, and cluster formation of water. We propose a mechanistic model to describe these effects. Whereas desflurane and isoflurane displace water and reach their pure-component loadings at higher concentrations, sevoflurane is not able to do so. Water adsorption strongly benefits from adsorbed fluranes with an initial steep increase in water capacity and a subsequent displacement of water with increasing flurane concentration.
中文翻译：
吸入性麻醉剂在潮湿气氛中活性炭的吸附
卤代醚，尤其是氟醚，通常用作人和动物的医学治疗中的吸入麻醉剂。由于它们对临床医生构成健康风险并对全球变暖产生重大影响，因此需要在医院与室内空气隔离。本文介绍了地氟醚、异氟醚和七氟醚在 25 °C 下在干燥和潮湿气氛下在 1 bar 的活性炭 D47/3 上的吸附等温线。研究了 50 到 500 ppm 之间的痕量氟烷浓度和 10 到 50% 之间的相对湿度。使用磁悬浮天平和火焰离子化检测器同时测定氟醚和水的负载量。结果表明，相对湿度越高，活性炭的吸附能力越低。我们表明，氟醚和水的共吸附受分子大小、极化率和极性支配。这导致了有限的氟醚孔隙可及性、氟醚和碳表面的分散相互作用以及氟醚和水的极性相互作用。从等温线数据，我们得出机械效应，如预吸附水阻塞吸附位点、随着氟醚量的增加吸附水分子的置换以及水的簇形成。我们提出了一个机械模型来描述这些影响。尽管地氟醚和异氟醚在较高浓度下取代水并达到其纯组分负载，但七氟醚无法做到这一点。
更新日期：2022-07-21
中文翻译：
吸入性麻醉剂在潮湿气氛中活性炭的吸附
卤代醚，尤其是氟醚，通常用作人和动物的医学治疗中的吸入麻醉剂。由于它们对临床医生构成健康风险并对全球变暖产生重大影响，因此需要在医院与室内空气隔离。本文介绍了地氟醚、异氟醚和七氟醚在 25 °C 下在干燥和潮湿气氛下在 1 bar 的活性炭 D47/3 上的吸附等温线。研究了 50 到 500 ppm 之间的痕量氟烷浓度和 10 到 50% 之间的相对湿度。使用磁悬浮天平和火焰离子化检测器同时测定氟醚和水的负载量。结果表明，相对湿度越高，活性炭的吸附能力越低。我们表明，氟醚和水的共吸附受分子大小、极化率和极性支配。这导致了有限的氟醚孔隙可及性、氟醚和碳表面的分散相互作用以及氟醚和水的极性相互作用。从等温线数据，我们得出机械效应，如预吸附水阻塞吸附位点、随着氟醚量的增加吸附水分子的置换以及水的簇形成。我们提出了一个机械模型来描述这些影响。尽管地氟醚和异氟醚在较高浓度下取代水并达到其纯组分负载，但七氟醚无法做到这一点。
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