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Serum Retinol Binding Protein 4 as a Potential Biomarker for Sarcopenia in Older Adults
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 4.3 ) Pub Date : 2022-07-20 , DOI: 10.1093/gerona/glac151 Chen-Lu Chang 1, 2 , Yan-Ru Li 1, 2 , Zhi-Yue Wang 1, 2 , Mei-Lin Li 1, 2 , Kai-Yue Jia 1, 2 , Hui-Xian Sun 1, 2 , Quan Wang 1, 2 , Can Zhao 1, 2 , Xiang Lu 1, 2 , Wei Gao 1, 2
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 4.3 ) Pub Date : 2022-07-20 , DOI: 10.1093/gerona/glac151 Chen-Lu Chang 1, 2 , Yan-Ru Li 1, 2 , Zhi-Yue Wang 1, 2 , Mei-Lin Li 1, 2 , Kai-Yue Jia 1, 2 , Hui-Xian Sun 1, 2 , Quan Wang 1, 2 , Can Zhao 1, 2 , Xiang Lu 1, 2 , Wei Gao 1, 2
Affiliation
Sarcopenia is characterized by progressive loss of muscle mass and function due to aging. Retinol-binding protein 4 (RBP4) is an adipokine with pro-inflammatory effects. However, the change of RBP4 concentration and its role in sarcopenia remains unclear. The aim of this study was to evaluate the association of serum RBP4 level with sarcopenia in the older adults. A total of 816 community dwelling older adults aged ≥60 years were enrolled. Serum RBP4 was measured by enzyme-linked immunosorbent assay. Appendicular skeletal muscle mass index (ASMI), grip strength, and gait speed were measured. We found that serum RBP4 levels were higher in patients with sarcopenia when compared to those without sarcopenias [44.3 (33.9-57.7) vs. 38.0 (28.0-48.4) μg/mL]. Receiver operating characteristic curve analysis indicated that the optimal cut-off value of serum RBP4 level that predicted sarcopenia was 38.79 μg/mL with a sensitivity of 67.8% and a specificity of 53.3%. Multivariate logistic regression analysis showed that the subjects with higher level of RBP4 had a higher risk of sarcopenia (adjusted OR =2.036, 95%CI =1.449-2.861). Serum RBP4 concentration was negatively correlated with grip strength (r =-0.098), gait speed (r =-0.186), and AMSI (r =-0.096). Moreover, serum RBP4 levels were higher in patients with severe sarcopenia when compared to those with moderate sarcopenia [49.0 (37.3-61.2) vs. 40.4 (31.3-51.2) μg/mL]. Taken together, our results demonstrate that serum RBP4 level is correlated with the risk and severity of sarcopenia in the older adults, indicating that RBP4 might serve as a surrogate biomarker for the screening and evaluation of sarcopenia.
中文翻译：
血清视黄醇结合蛋白 4 作为老年人肌肉减少症的潜在生物标志物
肌肉减少症的特征是由于衰老导致肌肉质量和功能逐渐丧失。视黄醇结合蛋白 4 (RBP4) 是一种具有促炎作用的脂肪因子。然而，RBP4 浓度的变化及其在肌肉减少症中的作用仍不清楚。本研究的目的是评估血清 RBP4 水平与老年人肌肉减少症的关系。共有 816 名年龄≥60 岁的社区居住老年人入组。通过酶联免疫吸附测定法测量血清 RBP4。测量附肢骨骼肌质量指数 (ASMI)、握力和步态速度。我们发现，与没有肌肉减少症的患者相比，肌肉减少症患者的血清 RBP4 水平更高 [44.3 (33.9-57.7) vs. 38.0 (28.0-48.4) μg/mL]。受试者工作特征曲线分析表明，血清 RBP4 水平预测肌肉减少症的最佳临界值为 38.79 μg/mL，敏感性为 67.8%，特异性为 53.3%。多因素logistic回归分析显示，RBP4水平较高的受试者发生肌肉减少症的风险较高（调整后的OR=2.036，95%CI=1.449-2.861）。血清 RBP4 浓度与握力 (r =-0.098)、步态速度 (r =-0.186) 和 AMSI (r =-0.096) 呈负相关。此外，与中度肌肉减少症患者相比，重度肌肉减少症患者的血清 RBP4 水平更高 [49.0 (37.3-61.2) vs. 40.4 (31.3-51.2) μg/mL]。综上所述，我们的结果表明血清 RBP4 水平与老年人肌肉减少症的风险和严重程度相关，
更新日期：2022-07-20
中文翻译：
血清视黄醇结合蛋白 4 作为老年人肌肉减少症的潜在生物标志物
肌肉减少症的特征是由于衰老导致肌肉质量和功能逐渐丧失。视黄醇结合蛋白 4 (RBP4) 是一种具有促炎作用的脂肪因子。然而，RBP4 浓度的变化及其在肌肉减少症中的作用仍不清楚。本研究的目的是评估血清 RBP4 水平与老年人肌肉减少症的关系。共有 816 名年龄≥60 岁的社区居住老年人入组。通过酶联免疫吸附测定法测量血清 RBP4。测量附肢骨骼肌质量指数 (ASMI)、握力和步态速度。我们发现，与没有肌肉减少症的患者相比，肌肉减少症患者的血清 RBP4 水平更高 [44.3 (33.9-57.7) vs. 38.0 (28.0-48.4) μg/mL]。受试者工作特征曲线分析表明，血清 RBP4 水平预测肌肉减少症的最佳临界值为 38.79 μg/mL，敏感性为 67.8%，特异性为 53.3%。多因素logistic回归分析显示，RBP4水平较高的受试者发生肌肉减少症的风险较高（调整后的OR=2.036，95%CI=1.449-2.861）。血清 RBP4 浓度与握力 (r =-0.098)、步态速度 (r =-0.186) 和 AMSI (r =-0.096) 呈负相关。此外，与中度肌肉减少症患者相比，重度肌肉减少症患者的血清 RBP4 水平更高 [49.0 (37.3-61.2) vs. 40.4 (31.3-51.2) μg/mL]。综上所述，我们的结果表明血清 RBP4 水平与老年人肌肉减少症的风险和严重程度相关，
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