Excess fibroblast growth factor (FGF) 23 signaling in patients with chronic kidney disease induces left ventricular hypertrophy. In this issue, Yanucil et al. investigated the interaction of soluble klotho and heparin with FGF23 and FGF receptor isoforms. They concluded that heparin promotes the FGF23–FGF receptor isoform 4 interaction and FGF23 pathogenic effects, supporting an important role of heparin in the pathogenesis of FGF23-mediated left ventricular hypertrophy in chronic kidney disease.

中文翻译：

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肝素、klotho 和 FGF23：不和谐心脏的三拍华尔兹

慢性肾病患者中过量的成纤维细胞生长因子 (FGF) 23 信号传导会导致左心室肥厚。在本期中，Yanucil等人。研究了可溶性 klotho 和肝素与 FGF23 和 FGF 受体亚型的相互作用。他们得出的结论是，肝素促进 FGF23-FGF 受体亚型 4 相互作用和 FGF23 致病作用，支持肝素在慢性肾脏病中 FGF23 介导的左心室肥厚发病机制中的重要作用。