Emerging approaches that enable high-throughput analysis of the plasma proteome have been increasingly deployed in nephrology research. Kobayashi et al. provide a valuable addition to this literature, describing an untargeted proteomic analysis of diabetic kidney disease progression to end-stage kidney disease. This commentary places the study’s findings in the context of the broader literature and outlines potential avenues toward biological insight and clinical utility.

中文翻译：

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糖尿病肾病中的蛋白质组学发现——目的是什么？

能够对血浆蛋白质组进行高通量分析的新兴方法已越来越多地应用于肾脏病学研究。小林等人。为该文献提供了有价值的补充，描述了糖尿病肾病进展到终末期肾病的非靶向蛋白质组学分析。本评论将研究结果置于更广泛的文献背景下，并概述了实现生物学洞察力和临床效用的潜在途径。