Cryoglobulinemia encompasses a group of diseases with circulating aberrant Igs, which can cause systemic cryoglobulinemic vasculitis, including cryoglobulinemic glomerulonephritis. The complexities of different types and changing etiologies of cryoglobulinemias determine its heterogeneous clinical manifestations and diagnostic difficulties. In this issue of Kidney International, Javaugue et al. have emphasized the diagnostic points of cryoglobulinemic glomerulonephritis and hematological disorders as the major culprits of noninfectious cryoglobulinemic glomerulonephritis in a large cohort.

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认识非感染性冷球蛋白血症性肾小球肾炎的真面目

冷球蛋白血症包括一组具有循环异常 Igs 的疾病，可引起系统性冷球蛋白血症性血管炎，包括冷球蛋白血症性肾小球肾炎。冷球蛋白血症不同类型的复杂性和不断变化的病因决定了其异质的临床表现和诊断困难。在本期《肾脏国际》中，Javaugue等人。强调冷球蛋白血症性肾小球肾炎和血液系统疾病的诊断要点是大型队列中非感染性冷球蛋白血症性肾小球肾炎的主要罪魁祸首。