Several studies have examined gut microbiota and sarcopenia using 16S ribosomal RNA amplicon sequencing; however, this technique may not be able to identify altered specific species and functional capacities of the microbes. We performed shotgun metagenomic sequencing to compare the gut microbiome composition and function between individuals with and without sarcopenia.

中文翻译：

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基于人群的宏基因组学分析揭示了肌肉减少症肠道微生物组的改变：来自湘雅肌肉减少症研究的数据

几项研究使用 16S 核糖体 RNA 扩增子测序检查了肠道微生物群和肌肉减少症；然而，这种技术可能无法识别微生物改变的特定物种和功能能力。我们进行了鸟枪法宏基因组测序，以比较患有和未患有肌肉减少症的个体之间的肠道微生物组组成和功能。