Activation of sphingomyelinase (SMase) as a result of a general inflammatory response has been implicated as a mechanism underlying disease-related loss of skeletal muscle mass and function in several clinical conditions including heart failure. Here, for the first time, we characterize the effects of SMase activity on human muscle fibre contractile function and assess skeletal muscle SMase activity in heart failure patients.

中文翻译：

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鞘磷脂酶活性促进人体肌肉纤维的萎缩和减弱力量，并在心力衰竭患者中升高

作为一般炎症反应的结果，鞘磷脂酶 (SMase) 的激活被认为是包括心力衰竭在内的几种临床病症中与疾病相关的骨骼肌质量和功能丧失的潜在机制。在这里，我们首次描述了 SMase 活性对人体肌肉纤维收缩功能的影响，并评估了心力衰竭患者的骨骼肌 SMase 活性。