The illustrated compounds, including natural products 3 and 7, confer neuroprotective effects on, for example, hydrogen-peroxide challenged mouse brain cortical cultures. They likely do so by acting as Michael acceptors and thereby upregulating the Keap1-Nrf2-ARE pathway.

中文翻译：

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核糖蛋白和某些类似物通过激活 Keap1-Nrf2-ARE 通路发挥神经保护作用

举例说明的化合物，包括天然产物3和7，对例如过氧化氢攻击的小鼠大脑皮层培养物具有神经保护作用。他们可能通过充当迈克尔受体并因此上调 Keap1-Nrf2-ARE 途径来做到这一点。