Abstract

Although the pathophysiology of paroxysmal atrial fibrillation (PAF) is not fully known, oxidative stress (OS) and atrial remodeling seem to be important triggers. Autophagy and apoptosis which are the types of cell death are fundamental processes in the human body. Although they investigated in many diseases, no study evaluated these parameters in PAF patients. We aimed to investigate autophagy and apoptosis which may be associated with atrial remodeling, and to show whether these factors are associated with OS in PAF patients. In this study, 44 PAF patients admitted to our clinic and 44 healthy volunteers were included. Serum total oxidative stress (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and ATG5 for autophagy and serum M30 for apoptosis were studied. Serum TOS, OSI, ATG5, M30 and left atrium (LA) diameter were higher, while TAS was lower in PAF group than the control group (p < 0.001, for all). ATG5 was positively correlated with TOS, OSI and LA, whereas negatively correlated with TAS. Also, M30 was positively correlated with TOS and OSI, whereas negatively correlated with TAS. Logistic regression analysis showed that TOS (P = 0.002), ATG5 (p = 0.013) and M30 (p = 0.006) were independent predictors of the PAF. It also found that ATG5 was the only independent predictor of LA enlargement in linear regression analysis. Our study showed that ATG5 and M30 were increased, and they were correlated with OS in patients with PAF. Therefore, we suggest that autophagy and apoptosis may play an important role in the PAF process.

摘要

虽然阵发性心房颤动 (PAF) 的病理生理学尚不完全清楚，但氧化应激 (OS) 和心房重构似乎是重要的触发因素。作为细胞死亡类型的自噬和细胞凋亡是人体的基本过程。尽管他们研究了许多疾病，但没有研究评估 PAF 患者的这些参数。我们旨在研究可能与心房重构相关的自噬和细胞凋亡，并显示这些因素是否与 PAF 患者的 OS 相关。在这项研究中，我们诊所收治了 44 名 PAF 患者和 44 名健康志愿者。研究了血清总氧化应激（TOS）、总抗氧化状态（TAS）、氧化应激指数（OSI）和自噬的ATG5和细胞凋亡的血清M30。血清 TOS、OSI、ATG5、p < 0.001，全部）。ATG5与TOS、OSI和LA呈正相关，与TAS呈负相关。此外，M30 与 TOS 和 OSI 呈正相关，而与 TAS 呈负相关。Logistic 回归分析显示 TOS (P = 0.002)、ATG5 ( p = 0.013) 和 M30 ( p = 0.006) 是 PAF 的独立预测因子。它还发现 ATG5 是线性回归分析中 LA 扩大的唯一独立预测因子。我们的研究表明，ATG5 和 M30 升高，并且与 PAF 患者的 OS 相关。因此，我们认为自噬和细胞凋亡可能在 PAF 过程中起重要作用。