Wearable sweat sensors with various sensing systems can provide noninvasive medical diagnostics and healthcare monitoring. Here, we demonstrate a wearable microfluidic nanoplasmonic sensor capable of refreshable and portable recognition fingerprint information of targeted biomarkers including urea, lactate, and pH in sweat. A miniature, thin plasmonic metasurface with homogeneous mushroom-shaped hot spots and high surface-enhanced Raman scattering (SERS) activity is designed and integrated into a microfluidics platform. Compared to conventional wearable SERS platforms with the risk of mixed effect between new and old sweat, the microfluidic SERS system allows sweat administration in a controllable and high temporal-resolution fashion, providing refreshable SERS analysis. We use a portable and customized Raman analyzer with a friendly human-machine interface for portable recognition of the spectroscopic signatures of sweat biomarkers. This study integrates epidermal microfluidics with portable SERS molecular recognition, presenting a controllable, handy, and dynamical biofluid sensing system for personalized medicine.

具有各种传感系统的可穿戴汗液传感器可以提供无创医疗诊断和医疗保健监测。在这里，我们展示了一种可穿戴的微流体纳米等离子体传感器，该传感器能够刷新和便携式识别目标生物标志物的指纹信息，包括尿素、乳酸和汗液中的 pH 值。设计了一种具有均匀蘑菇状热点和高表面增强拉曼散射 (SERS) 活性的微型薄等离子体超表面，并将其集成到微流体平台中。与具有新旧汗液混合效应风险的传统可穿戴 SERS 平台相比，微流体 SERS 系统允许以可控和高时间分辨率的方式进行汗液管理，提供可刷新的 SERS 分析。我们使用具有友好人机界面的便携式定制拉曼分析仪来便携式识别汗液生物标志物的光谱特征。本研究将表皮微流体与便携式 SERS 分子识别相结合，为个性化医疗提供了一种可控、方便、动态的生物流体传感系统。