Elucidating potentially causal factors for depression and the direction of their impact could beneficially inform prevention strategies. Mendelian randomization revealed the protective role of increased relative carbohydrate intake in lowering depression risk. In addition, body mass index mediated this effect but to a lesser extent than the total effect size.

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相对碳水化合物摄入对抑郁症的保护作用

阐明抑郁症的潜在致病因素及其影响方向可以有益地为预防策略提供信息。孟德尔随机化揭示了增加相对碳水化合物摄入量对降低抑郁症风险的保护作用。此外，体重指数介导了这种影响，但其影响程度小于总影响大小。