Systemic sclerosis–associated interstitial lung disease (SSc-ILD) is the leading cause of death in patients with SSc with unclear pathogenesis and limited treatment options. Evidence strongly supports an important role for profibrotic secreted phosphoprotein 1 (SPP1)–expressing macrophages in SSc-ILD. This study was undertaken to define the transcriptome and chromatin structural changes of SPP1 SSc-ILD macrophages in order to better understand their role in promoting fibrosis and to identify transcription factors associated with open chromatin driving their altered phenotype.

中文翻译：

---

系统性硬化症相关间质性肺病中促纤维化巨噬细胞的表观遗传调控

系统性硬化症相关间质性肺病 (SSc-ILD) 是 SSc 患者死亡的主要原因，发病机制不明且治疗选择有限。证据强烈支持表达促纤维化分泌性磷蛋白 1 (SPP1) 的巨噬细胞在 SSc-ILD 中的重要作用。本研究旨在确定 SPP1 SSc-ILD 巨噬细胞的转录组和染色质结构变化，以便更好地了解它们在促进纤维化中的作用，并确定与开放染色质驱动其表型改变相关的转录因子。