The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of therapeutic resistance may provide new strategies for overcoming cancer resistance. N6-methyladenosine (m6A) is the most prevalent RNA modification in eukaryotes, and is involved in the regulation of RNA splicing, translation, transport, degradation, stability and processing, thus affecting several physiological processes and cancer progression. As a novel type of multifunctional non-coding RNAs (ncRNAs), circular RNAs (circRNAs) have been demonstrated to play vital roles in anticancer therapy. Currently, accumulating studies have revealed the mutual regulation of m6A modification and circRNAs, and their interaction can further influence the sensitivity of cancer treatment. In this review, we mainly summarized the recent advances of m6A modification and circRNAs in the modulation of cancer therapeutic resistance, as well as their interplay and potential mechanisms, providing promising insights and future directions in reversal of therapeutic resistance in cancer.

中文翻译：

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N6-甲基腺苷 (m6A) 修饰与癌症中环状 RNA 的相互调节：对治疗耐药性的影响

肿瘤细胞对治疗的抵抗力严重影响治疗效果，导致各种癌症的复发和转移。阐明治疗耐药性的潜在机制可能为克服癌症耐药性提供新的策略。N6-甲基腺苷 (m6A) 是真核生物中最普遍的 RNA 修饰，参与 RNA 剪接、翻译、转运、降解、稳定性和加工的调控，从而影响多种生理过程和癌症进展。作为一种新型的多功能非编码 RNA (ncRNA)，环状 RNA (circRNA) 已被证明在抗癌治疗中发挥重要作用。目前，越来越多的研究揭示了m6A修饰与circRNA的相互调控，它们的相互作用可以进一步影响癌症治疗的敏感性。在这篇综述中，我们主要总结了 m6A 修饰和 circRNAs 在调节癌症治疗耐药性方面的最新进展，以及它们的相互作用和潜在机制，为逆转癌症治疗耐药性提供了有希望的见解和未来方向。