The COVID-19 pandemic has influenced organ transplantation decision making. Opinions regarding the utilization of coronavirus disease-2019 (COVID-19) donors are mixed. We hypothesize that COVID-19 infection of deceased solid organ transplant donors does not affect recipient survival. All deceased solid organ transplant donors with COVID-19 testing results from March 15, 2020 to September 30, 2021 were identified in the OPTN database. Donors were matched to recipients and stratified by the COVID-19 test result. Outcomes were assessed between groups. COVID-19 test results were available for 17 694 donors; 150 were positive. A total of 269 organs were transplanted from these donors, including 187 kidneys, 57 livers, 18 hearts, 5 kidney-pancreases, and 2 lungs. The median time from COVID-19 testing to organ recovery was 4 days for positive and 3 days for negative donors. Of these, there were 8 graft failures (3.0%) and 5 deaths (1.9%). Survival of patients receiving grafts from COVID-19-positive donors is equivalent to those receiving grafts from COVID-19-negative donors (30-day patient survival = 99.2% COVID-19 positive; 98.6% COVID-19 negative). Solid organ transplantation using deceased donors with positive COVID-19 results does not negatively affect early patient survival, though little information regarding donor COVID-19 organ involvement is known. While transplantation is feasible, more information regarding COVID-19-positive donor selection is needed.

中文翻译：

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使用 COVID-19 阳性已故捐献者进行器官移植

COVID-19 大流行影响了器官移植决策。关于 2019 年冠状病毒病 (COVID-19) 捐助者的利用意见不一。我们假设已故实体器官移植捐赠者感染 COVID-19 不会影响接受者的存活。OPTN 数据库中确定了 2020 年 3 月 15 日至 2021 年 9 月 30 日期间具有 COVID-19 检测结果的所有已故实体器官移植捐赠者。捐赠者与接受者相匹配，并根据 COVID-19 测试结果进行分层。结果在各组之间进行评估。17 694 名捐赠者获得了 COVID-19 检测结果；150 人呈阳性。这些捐赠者共移植了269个器官，包括187个肾脏、57个肝脏、18个心脏、5个肾胰脏和2个肺。从 COVID-19 测试到器官恢复的中位时间对于阳性捐赠者为 4 天，对于阴性捐赠者为 3 天。其中，有 8 例移植失败 (3.0%) 和 5 例死亡 (1.9%)。接受 COVID-19 阳性供体移植物的患者的存活率与接受 COVID-19 阴性供体移植物的患者相同（30 天患者存活率 = 99.2% COVID-19 阳性；98.6% COVID-19 阴性）。使用 COVID-19 结果呈阳性的已故供体进行实体器官移植不会对早期患者的生存产生负面影响，尽管关于供体 COVID-19 器官受累的信息知之甚少。虽然移植是可行的，但需要更多关于 COVID-19 阳性供体选择的信息。接受 COVID-19 阳性供体移植物的患者的存活率与接受 COVID-19 阴性供体移植物的患者相同（30 天患者存活率 = 99.2% COVID-19 阳性；98.6% COVID-19 阴性）。使用 COVID-19 结果呈阳性的已故供体进行实体器官移植不会对早期患者的生存产生负面影响，尽管关于供体 COVID-19 器官受累的信息知之甚少。虽然移植是可行的，但需要更多关于 COVID-19 阳性供体选择的信息。接受 COVID-19 阳性供体移植物的患者的存活率与接受 COVID-19 阴性供体移植物的患者相同（30 天患者存活率 = 99.2% COVID-19 阳性；98.6% COVID-19 阴性）。使用 COVID-19 结果呈阳性的已故供体进行实体器官移植不会对早期患者的生存产生负面影响，尽管关于供体 COVID-19 器官受累的信息知之甚少。虽然移植是可行的，但需要更多关于 COVID-19 阳性供体选择的信息。尽管关于供体 COVID-19 器官受累的信息知之甚少。虽然移植是可行的，但需要更多关于 COVID-19 阳性供体选择的信息。尽管关于供体 COVID-19 器官受累的信息知之甚少。虽然移植是可行的，但需要更多关于 COVID-19 阳性供体选择的信息。