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Intercomparison study of fragmentation pathways and fragment ion structures for screening of illegal drugs and their novel analogues used to adulterate dietary supplements using liquid chromatography/quadrupole time-of-flight mass spectrometry
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2022-07-13 , DOI: 10.1002/rcm.9353
Nam Sook Kim 1 , Hwan Seong Choi 1 , Na Young Lim 1 , Ji Hyun Lee 1 , Hyungil Kim 1 , Sun Young Baek 1
Affiliation  

As public interest in health and immunity has increased in recent years, so has the demand for dietary supplements. However, supplements adulterated with illegal drugs and their novel analogues are being sold even as the pharmacological efficacies of these drugs are being advertised. Since the use of these illegal compounds can have serious side effects, they pose a risk to public health. Hence, in this study, we propose a strategy for proactively testing drugs and novel analogues that may be added to dietary supplements illegally.

中文翻译:

使用液相色谱/四极杆飞行时间质谱法对用于掺假膳食补充剂的非法药物及其新型类似物筛选的碎片途径和碎片离子结构进行比对研究

近年来,随着公众对健康和免疫的兴趣增加,对膳食补充剂的需求也随之增加。然而,即使在宣传这些药物的药理功效的同时,掺入非法药物及其新型类似物的补充剂仍在销售。由于使用这些非法化合物会产生严重的副作用,因此会对公众健康构成风险。因此,在这项研究中,我们提出了一种主动测试可能非法添加到膳食补充剂中的药物和新型类似物的策略。
更新日期:2022-07-13
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