The landscape of metabolic brain alterations in Alzheimer's disease,Alzheimer's & Dementia

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The landscape of metabolic brain alterations in Alzheimer's disease
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2022-07-13 , DOI: 10.1002/alz.12714
Richa Batra ₁ , Matthias Arnold _{2,

3} , Maria A Wörheide ₃ , Mariet Allen ₄ , Xue Wang ₅ , Colette Blach ₂ , Allan I Levey ₆ , Nicholas T Seyfried ₇ , Nilüfer Ertekin-Taner _{4,

8} , David A Bennett ₉ , Gabi Kastenmüller ₃ , Rima F Kaddurah-Daouk ₁₀ , Jan Krumsiek ₁ ,

Affiliation

Department of Physiology and Biophysics, Institute for Computational Biomedicine, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, USA.
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.
Institute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, USA.
Department of Health Sciences Research, Mayo Clinic Florida, Jacksonville, Florida, USA.
Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, Georgia, USA.
Department of Biochemistry, Emory School of Medicine, Jacksonville, Florida, USA.
Department of Neurology, Mayo Clinic Florida, Jacksonville, Florida, USA.
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, North Carolina, USA.

Alzheimer's disease (AD) is accompanied by metabolic alterations both in the periphery and the central nervous system. However, so far, a global view of AD-associated metabolic changes in the brain has been missing.

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