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Multimodal Therapies against Pancreatic Ductal Adenocarcinoma: A Review on Synergistic Approaches toward Ultimate Nanomedicine Treatments
Advanced Therapeutics ( IF 3.7 ) Pub Date : 2022-07-12 , DOI: 10.1002/adtp.202200079 Marzia Conte 1 , Valentina Cauda 1
Advanced Therapeutics ( IF 3.7 ) Pub Date : 2022-07-12 , DOI: 10.1002/adtp.202200079 Marzia Conte 1 , Valentina Cauda 1
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In the last decades, extensive research has been carried out on the understanding and treatment of pancreatic cancer. Despite the significant advances in medicine and nanotechnology, there is an increasing concern about the lack of a standardized therapy with favorable outcomes for patients affected by this malignant disease, whose survival rates are nowadays far alarmingly low. The aim of this review is to offer a comprehensive view on the topic, by drawing upon two strands of research into pancreatic cancer. First, a detailed overview on the tumor genesis, progression, and resulting intricate microenvironment is presented. Thereafter, an extensive insight into the current treatments and their evolution throughout time, with a major focus on nanomedicine approaches, are offered to the reader. With respect to previous studies, a particular emphasis is given here to innovative theranostic approaches. In the light of what is now well established by recent evidence, the focus is given to multimodal treatments involving the combination of different therapies and, in particular, of nanoparticle-based medicine. The challenging purpose is finally of shedding light on future ultimate treatments out of the currently followed well-worn paths.
中文翻译：
胰腺导管腺癌的多模式治疗：终极纳米医学治疗的协同方法综述
在过去的几十年里，人们对胰腺癌的认识和治疗进行了广泛的研究。尽管医学和纳米技术取得了重大进步，但人们越来越担心缺乏一种标准化疗法，这种疗法对受这种恶性疾病影响的患者具有良好的疗效，如今这些患者的存活率低得惊人。本综述的目的是通过借鉴对胰腺癌的两方面研究，提供对该主题的全面看法。首先，详细概述了肿瘤的发生、发展和由此产生的错综复杂的微环境。此后，向读者提供了对当前治疗及其随时间演变的广泛见解，主要关注纳米医学方法。相对于以往的研究，这里特别强调创新的治疗诊断方法。鉴于最近的证据已经确立，重点是多模式治疗，涉及不同疗法的组合，特别是基于纳米粒子的药物。具有挑战性的目的最终是从目前遵循的陈旧路径中阐明未来的最终治疗方法。
更新日期：2022-07-12
中文翻译：
胰腺导管腺癌的多模式治疗：终极纳米医学治疗的协同方法综述
在过去的几十年里，人们对胰腺癌的认识和治疗进行了广泛的研究。尽管医学和纳米技术取得了重大进步，但人们越来越担心缺乏一种标准化疗法，这种疗法对受这种恶性疾病影响的患者具有良好的疗效，如今这些患者的存活率低得惊人。本综述的目的是通过借鉴对胰腺癌的两方面研究，提供对该主题的全面看法。首先，详细概述了肿瘤的发生、发展和由此产生的错综复杂的微环境。此后，向读者提供了对当前治疗及其随时间演变的广泛见解，主要关注纳米医学方法。相对于以往的研究，这里特别强调创新的治疗诊断方法。鉴于最近的证据已经确立，重点是多模式治疗，涉及不同疗法的组合，特别是基于纳米粒子的药物。具有挑战性的目的最终是从目前遵循的陈旧路径中阐明未来的最终治疗方法。
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