Disulfiram, a drug prescribed for the treatment of alcohol use disorders for more than 60 years, has recently been repurposed for cancer treatment. New work in The EMBO Journal now describes a disulfiram role in immunotherapy of cancer, involving direct binding to Lck to mediate activation of tumor-infiltrating T cells.

中文翻译：

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双硫仑从橡胶硫化到 T 细胞激活的历程

双硫仑是一种治疗酒精使用障碍的药物，已有 60 多年的历史，最近被重新用于癌症治疗。EMBO 杂志上的新研究现在描述了双硫仑在癌症免疫治疗中的作用，涉及直接结合 Lck 以介导肿瘤浸润 T 细胞的激活。