Introduction: The study was designed to assess the prevalence of pregnancy and delivery associated risk factors in children suffering from neonatal or presumed periventricular venous infarction. Methods: Antenatal records and pregnancy outcome data were retrospectively assessed in children with presumed periventricular venous infarction (n = 43, born ≥36 gestational weeks) or neonatal periventricular venous infarction (n = 86, born <36 gestational weeks) and compared to a matched control group (n = 2168, ≥36 gestational weeks) from a prospective study. Results: Children with presumed periventricular venous infarction had significantly more maternal bacterial infections compared to the control group (47% vs 20%, respectively, P < .001), whereas no difference was found compared to the neonatal periventricular venous infarction group (49%, P = .80). Mothers with bacterial infection in the presumed periventricular venous infarction group had significantly more often pyelonephritis compared to the control group (50% vs 3.4%, respectively, P < .001). Conclusions: Our data show an increased risk for developing periventricular venous infarction in the case of maternal bacterial infections, especially between gestational weeks 21 and 31.

简介：该研究旨在评估患有新生儿或推测的脑室周围静脉梗塞的儿童中妊娠和分娩相关危险因素的患病率。方法：回顾性评估推定脑室周围静脉梗塞（n = 43，出生≥36 孕周）或新生儿脑室周围静脉梗塞（n = 86，出生 <36 孕周）的儿童的产前记录和妊娠结局数据，并与匹配的来自一项前瞻性研究的对照组（n = 2168，≥36 孕周）。结果：与对照组相比，推测为脑室周围静脉梗塞的儿童的母体细菌感染显着增加（分别为 47% 和 20%，P < .001)，而与新生儿脑室周围静脉梗塞组相比没有发现差异 (49%, P  = .80)。与对照组相比，假定脑室周围静脉梗塞组发生细菌感染的母亲发生肾盂肾炎的频率显着高于对照组（分别为 50% 和 3.4%，P  < .001）。结论：我们的数据显示，在母体细菌感染的情况下，发生脑室周围静脉梗塞的风险增加，尤其是在妊娠 21 至 31 周之间。