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HFIP in Organic Synthesis
Chemical Reviews ( IF 51.4 ) Pub Date : 2022-07-17 , DOI: 10.1021/acs.chemrev.1c00749
Hashim F Motiwala 1 , Ahlam M Armaly 1 , Jackson G Cacioppo 1 , Thomas C Coombs 2 , Kimberly R K Koehn 1 , Verrill M Norwood 1 , Jeffrey Aubé 1
Affiliation  

1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic species, transfer protons, and engage in a range of other intermolecular interactions. The use of this solvent has exponentially increased in the past decade and has become a solvent of choice in some areas, such as C–H functionalization chemistry. In this review, following a brief history of HFIP in organic synthesis and an overview of its physical properties, literature examples of organic reactions using HFIP as a solvent or an additive are presented, emphasizing the effect of solvent of each reaction.

中文翻译:

HFIP 在有机合成中的应用

1,1,1,3,3,3-六氟异丙醇 (HFIP) 是一种极性、强氢键供给溶剂,由于其稳定离子物质、转移质子和参与有机合成的能力,在有机合成中有着广泛的用途。其他分子间相互作用的范围。在过去十年中,这种溶剂的使用呈指数级增长,并已成为某些领域(例如 C-H 官能化化学)的首选溶剂。在这篇综述中,在简要介绍了 HFIP 在有机合成中的历史及其物理性质的概述之后,介绍了使用 HFIP 作为溶剂或添加剂的有机反应的文献实例,强调了每个反应中溶剂的影响。
更新日期:2022-07-17
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