A core–shell magnetic metal–organic framework (Fe₃O₄ SiO₂/ PAEDTC@ MIL- 101 (Fe)) was synthesized as the substrate and then covered with a surface molecularly imprinted polymer (MIP) layer. Next, Fe₃O₄ SiO₂/ PAEDTC@ MIL- 101 (Fe) @ MIP was characterized by XRD, FT-IR, BET, VSM, TEM, and FE-SEM techniques and applied for selective, fast, and sensitive magnetic dispersive solid-phase microextraction (M-DµSPE) of diazinon from urine samples by the GC- FID detection method. The key experimental variables affecting M-DµSPE were studied and optimized by central composite design (CCD). Under optimum conditions (5 mL; sample at pH: 7.0, the mass of solid sorbent; 6 mg, extraction time; 4 min, acetonitrile as an eluent solvent; 1.5 mL, and desorption time; 3 min, and then reconstituted with 100 µL of methanol), the proposed method exhibits high sensitivity with limits of detection and quantification of 0.005 and 0.017 ng mL⁻¹, respectively. Excellent extraction recovery (98.5 %), wide linearity range (0.02–200000 ng mL⁻¹, R² > 0.992), high enrichment factors (47–53), and satisfactory precision (<6.3 % RSD) were achieved. The MIP- MOF@ M-DµSPE -GC-FID method can be used with high precision and wide linearity to extract and analyze trace levels of diazinon in real urine samples.

合成了核壳磁性金属有机骨架（Fe ₃ O ₄ SiO ₂ / PAEDTC@MIL-101 (Fe)）作为基底，然后覆盖有表面分子印迹聚合物（MIP）层。接下来，Fe ₃ O ₄ SiO ₂/ PAEDTC@MIL-101 (Fe)@MIP 通过 XRD、FT-IR、BET、VSM、TEM 和 FE-SEM 技术进行表征，并应用于选择性、快速、灵敏的磁分散固相微萃取 (M-DµSPE) ) 通过 GC-FID 检测方法从尿样中检测二嗪农。通过中心复合设计 (CCD) 研究和优化了影响 M-DµSPE 的关键实验变量。在最佳条件下（5 mL；样品 pH：7.0，固体吸附剂的质量；6 mg，萃取时间；4 分钟，乙腈作为洗脱溶剂；1.5 mL，解吸时间；3 分钟，然后用 100 µL 复溶甲醇），所提出的方法表现出高灵敏度，检测限和定量限分别为 0.005 和 0.017 ng mL ^-1。出色的萃取回收率 (98.5 %)，宽线性范围 (0.02–200000 ng mL)^-1 , R ²  > 0.992)、高富集因子 (47–53) 和令人满意的精密度 (<6.3 % RSD)。MIP-MOF@ M-DµSPE -GC-FID 方法可用于提取和分析真实尿样中痕量二嗪农，具有高精度和宽线性。