This study examines how perceived information overload and misinformation affect vaccine hesitancy and how this is moderated by structural and cultural factors. By applying and extending the fundamental cause theory, this study proposes a contextualized impact model to analyze a cross-national survey of 6034 residents in six societies in Asia, Europe and North America in June 2021. The study finds that (1) Older and highly-educated participants were less susceptible to COVID-19 information overload and belief in vaccine misinformation. (2) Perceived information overload led to an increase in vaccine acceptance and uptake, whereas belief in vaccine misinformation caused a decrease. (3) The structural differentiation of vaccine hesitancy was salient and higher socioeconomic status could buffer the negative impact of misinformation on vaccine acceptance. (4) Cultural factors such as collectivism and authoritarian mentality also served as buffers against the misinformation that reduced vaccine acceptance and uptake. These findings add nuanced footnotes to the fundamental causes theory and contribute to the discussion on the global recovery from the infodemic. Besides fact-checking and improving individual information literacy, effective and long-term information management and health policies must pay attention to stratified information gaps across socioeconomic groups, and to contextualize the communication and intervention strategies in different cultures.

这项研究探讨了感知信息超载和错误信息如何影响疫苗犹豫，以及结构和文化因素如何调节这种犹豫。通过应用和扩展根本原因理论，本研究提出了一个情境化影响模型来分析 2021 年 6 月对亚洲、欧洲和北美 6 个社会的 6034 名居民进行的跨国调查。研究发现，（1）年龄较大且高度-受过教育的参与者不太容易受到 COVID-19 信息过载和疫苗错误信息的影响。 (2) 感知信息超载导致疫苗接受度和采用率增加，而对疫苗错误信息的信念则导致疫苗接受度和采用率下降。 （3）疫苗犹豫的结构性分化明显，较高的社会经济地位可以缓冲错误信息对疫苗接受的负面影响。 (4) 集体主义和独裁心态等文化因素也可以缓冲错误信息，从而降低疫苗的接受度和使用率。这些发现为根本原因理论添加了细致入微的脚注，并有助于关于全球从信息流行病中复苏的讨论。除了事实核查和提高个人信息素养外，有效和长期的信息管理和卫生政策还必须关注社会经济群体之间的分层信息差距，并将沟通和干预策略置于不同文化的背景下。