Glutathione (GSH) plays vital roles in a variety of biological processes, and the development of simple and effective GSH detection method is an important research topic. Herein, a multifunctional probe based on Ag&Mn:ZnInS quantum dots (QDs) was developed for bimodal imaging of GSH. MnO₂, as an efficient fluorescence quencher, was in-situ grown on the surface of QDs, and then modified with hyaluronic acid (HA) to improve the stability and targeted recognition capability of the probe due to the binding between HA and CD44 receptors. After MnO₂ was deconstructed by GSH, the fluorescence of the probe was recovered and the generated Mn²⁺ could serve as good magnetic resonance imaging (MRI) contrast agent. Moreover, the near-infrared emission probe was successfully employed in living cell and zebrafish imaging due to its low toxicity and high anti-biological interference performance. This strategy provides a simple dual-mode fluorescence/MRI imaging of GSH, which may have a broad application in biological detection.

谷胱甘肽（GSH）在多种生物过程中发挥着至关重要的作用，开发简单有效的GSH检测方法是一个重要的研究课题。在此，开发了一种基于 Ag&Mn:ZnInS 量子点 (QD) 的多功能探针，用于 GSH 的双峰成像。MnO ₂作为一种高效的荧光猝灭剂，在量子点表面原位生长，然后用透明质酸（HA）修饰，通过HA与CD44受体结合，提高探针的稳定性和靶向识别能力。GSH解构MnO ₂后，探针荧光恢复，生成的Mn ²⁺可作为良好的磁共振成像 (MRI) 造影剂。此外，近红外发射探头因其低毒性和高抗生物干扰性能而成功用于活细胞和斑马鱼成像。该策略提供了一种简单的GSH双模式荧光/MRI成像，可能在生物检测中具有广泛的应用。