Layered double hydroxide is a family of two-dimensional materials with wide range of compositions. Recently, its ability to accommodate various chemical species and biocompatibility have been attracted in the biomedical applications to develop drug delivery system and nanodiagnostics. In this review, we categorized biomedical approaches of layered double hydroxide with respect to the three topologies of, namely, interlayer space, outer surface with particle edge, and the lattice points. There have been extensive researches on the intercalation of drug or tracing to make use of interlayer space of layered double hydroxide for drug stabilization, sustained release, cellular delivery and etc. Outer surface or edge has been utilized to immobilization of large therapeutic moieties and to attach tracing moiety. Lattice points consisting of various metal species could be utilized for the specific metal species like paramagnetic elements or radioisotopes. Based on these topologies in layered double hydroxide, both the synthetic routes and the achieved functionalities in terms of biomedical application will be discussed.

层状双氢氧化物是一类具有广泛成分的二维材料。最近，它适应各种化学物质和生物相容性的能力在生物医学应用中受到关注，以开发药物输送系统和纳米诊断学。在这篇综述中，我们根据层间空间、具有粒子边缘的外表面和晶格点这三种拓扑结构对层状双氢氧化物的生物医学方法进行了分类。利用层状双氢氧化物的层间空间进行药物稳定、缓释、细胞递送等，对药物的嵌入或示踪进行了广泛的研究。外表面或边缘已被用于固定大的治疗部分和附着示踪部分。由各种金属种类组成的晶格点可用于特定金属种类，如顺磁性元素或放射性同位素。基于层状双氢氧化物中的这些拓扑结构，将讨论合成路线和在生物医学应用方面实现的功能。