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Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets
Emerging Infectious Diseases ( IF 7.2 ) Pub Date : 2022-07-15 , DOI: 10.3201/eid2809.220879
Joanna A. Pulit-Penaloza , Jessica A. Belser , Nicole Brock , Poulami Basu Thakur , Terrence M. Tumpey , Taronna R. Maines

Highly pathogenic avian influenza A(H5N1) viruses have spread rapidly throughout North American flyways in recent months, affecting wild birds in over 40 states. We evaluated the pathogenicity and transmissibility of a representative virus using a ferret model and examined replication kinetics of this virus in human respiratory tract cells.



中文翻译:

北美高致病性甲型 H5N1 禽流感病毒在雪貂中的发病机制和传播能力

近几个月来,高致病性甲型 H5N1 禽流感病毒在整个北美迁徙路线上迅速传播,影响了 40 多个州的野生鸟类。我们使用雪貂模型评估了代表性病毒的致病性和传播能力,并检查了该病毒在人类呼吸道细胞中的复制动力学。

更新日期:2022-07-16
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