Highly pathogenic avian influenza A(H5N1) viruses have spread rapidly throughout North American flyways in recent months, affecting wild birds in over 40 states. We evaluated the pathogenicity and transmissibility of a representative virus using a ferret model and examined replication kinetics of this virus in human respiratory tract cells.

中文翻译：

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北美高致病性甲型 H5N1 禽流感病毒在雪貂中的发病机制和传播能力

近几个月来，高致病性甲型 H5N1 禽流感病毒在整个北美迁徙路线上迅速传播，影响了 40 多个州的野生鸟类。我们使用雪貂模型评估了代表性病毒的致病性和传播能力，并检查了该病毒在人类呼吸道细胞中的复制动力学。