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Enhancing Electrochemiluminescence Efficiency through Introducing Atomically Dispersed Ruthenium in Nickel-Based Metal–Organic Frameworks
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-07-15 , DOI: 10.1021/acs.analchem.2c02334
Guanhui Zhao 1 , Xue Dong 1 , Yu Du 1 , Nuo Zhang 1 , Guozhen Bai 1 , Dan Wu 1 , Hongmin Ma 1 , Yaoguang Wang 2 , Wei Cao 1 , Qin Wei 1
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The successful application of electrochemiluminescence (ECL) in various fields required continuous exploration of novel ECL signal emitters. In this work, we have proposed a pristine ECL luminophor named NiRu MOFs, which owned extremely high and stable ECL transmission efficiency and was synthesized via a straightforward two-step hydrothermal pathway. The foundation framework of pure Ni-MOFs with the initial structure was layered-pillared constructed by the coordinated octahedrally divalent between nickel and terephthalic acid (BDC). The terephthalates were coordinated and pillared directly to the nickel hydroxide layers and the three-dimensional framework was formed, which had a weak ECL response strength. Then, the ruthenium pyridine complex was recombined with pure Ni-MOFs to produce NiRu MOFs and part of the introduced ruthenium was atomically dispersed in the layered-pillared structure through an ion-exchange method, which led to the ECL luminous efficiency being significantly boosted more than pure Ni-MOFs. In order to verify the superiority of this newly synthesized illuminant, an ECL immunoassay model has been designed, and the results demonstrated that it had extremely strong and steady signal output in practical application. This study realized an efficient platform in ECL immunoassay application with the limit of detection of 0.32 pg mL–1 for neuron-specific enolase (NSE). Therefore, the approach which combined the pristine pure Ni-MOFs and the star-illuminant ruthenium pyridine complex would provide a convenient and meaningful solution for exploring the next-generation ECL emitters.

中文翻译:

通过在镍基金属-有机框架中引入原子分散的钌来提高电化学发光效率

电化学发光 (ECL) 在各个领域的成功应用需要不断探索新型 ECL 信号发射器。在这项工作中,我们提出了一种名为 NiRu MOFs 的原始 ECL 发光体,它具有极高且稳定的 ECL 传输效率,并通过简单的两步水热途径合成。具有初始结构的纯Ni-MOFs的基础框架是由镍和对苯二甲酸(BDC)之间的配位八面体二价位构成的层状柱状结构。对苯二甲酸酯直接配位并支撑在氢氧化镍层上,形成三维框架,其ECL响应强度较弱。然后,钌吡啶配合物与纯Ni-MOFs复合制备NiRu MOFs,部分引入的钌通过离子交换方法原子分散在层状柱状结构中,使得ECL发光效率比纯金属显着提高Ni-MOF。为了验证这种新合成的发光体的优越性,设计了一种ECL免疫分析模型,结果表明它在实际应用中具有极强且稳定的信号输出。本研究实现了一个高效的 ECL 免疫分析应用平台,检测限为 0.32 pg mL 为了验证这种新合成的发光体的优越性,设计了一种ECL免疫分析模型,结果表明它在实际应用中具有极强且稳定的信号输出。本研究实现了一个高效的 ECL 免疫分析应用平台,检测限为 0.32 pg mL 为了验证这种新合成的发光体的优越性,设计了一种ECL免疫分析模型,结果表明它在实际应用中具有极强且稳定的信号输出。本研究实现了一个高效的 ECL 免疫分析应用平台,检测限为 0.32 pg mL–1表示神经元特异性烯醇化酶 (NSE)。因此,结合原始纯Ni-MOFs和星光体钌吡啶配合物的方法将为探索下一代ECL发射器提供方便且有意义的解决方案。
更新日期:2022-07-15
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