Dual-emissive EY/UiO-66-NH2 as a ratiometric probe for turn-on sensing and cell imaging of hypochlorite,Analyst

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Dual-emissive EY/UiO-66-NH2 as a ratiometric probe for turn-on sensing and cell imaging of hypochlorite
Analyst ( IF 3.6 ) Pub Date : 2022-07-15 , DOI: 10.1039/d2an00944g
Fangfang Yu ₁ , Yihan Wang ₁ , Tengfei Liu ₁ , Xiaohui Liu ₁ , Hui Jiang ₁ , Xuemei Wang ₁

Affiliation

Hypochlorite plays a vital role in biological systems and our daily life. The rapid and convenient detection of hypochlorite is imperative and significant for disease treatment and human health. In this work, EY/UiO-66-NH₂ (EY = eosin Y) was prepared through a hydrothermal process and could be applied to the detection and bioimaging of hypochlorite as a self-calibrating sensing nanoprobe. EY/UiO-66-NH₂ features two emissions at 432 nm and 533 nm, and the emission intensity of 533 nm is enhanced with increasing ClO⁻ concentration. EY/UiO-66-NH₂ could be utilized as a ratiometric fluorescence sensor of ClO⁻. The linear range of EY/UiO-66-NH₂ towards ClO⁻ is 0.1–200 μM and its detection limit is 46.4 nM. In comparison with previously reported probes for ClO⁻, EY/UiO-66-NH₂ has the advantages of a wide linear range, low detection limit, turn-on fluorescence and ratiometric response. This work provides a new method for ClO⁻ detection in living cells.

中文翻译：

双发射 EY/UiO-66-NH2 作为比率探针用于次氯酸盐的开启传感和细胞成像

次氯酸盐在生物系统和我们的日常生活中起着至关重要的作用。次氯酸盐的快速便捷检测对于疾病治疗和人类健康至关重要。在这项工作中，EY/UiO-66-NH ₂ (EY = eosin Y)是通过水热法制备的，可作为一种自校准传感纳米探针应用于次氯酸盐的检测和生物成像。EY/UiO-66-NH ₂在 432 nm 和 533 nm 有两种发射，且 533 nm 的发射强度随着 ClO ^-浓度的增加而增强。EY/UiO-66-NH ₂可用作ClO ^-的比率荧光传感器。_{EY/UiO-66-NH 2}对ClO的线性范围^-为 0.1–200 μM，检测限为 46.4 nM。与之前报道的ClO ^-探针相比，EY/UiO-66-NH ₂具有线性范围宽、检测限低、开启荧光和比率响应等优点。这项工作为活细胞中的 ClO ^-检测提供了一种新方法。

更新日期：2022-07-15

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