Introduction

Distal radius fractures (DRF) are associated with increased risk of subsequent fractures and physical decline in older adults. This study aims to evaluate the risk cognitive decline following DRF and potential for timely screening and intervention.

Methods

A cohort of 1046 individuals 50–75 years of age with DRF were identified between 1995 and 2015 (81.5% female; mean age 62.5 [± 7.1] years). A control group (N = 1044) without history of DRF was matched by age, sex, and fracture date (i.e., index). The incidence of neurocognitive disorders (NCD) in relation to DRF/index was determined. Group comparisons were adjusted by age and comorbidity measured by the Elixhauser index.

Results

The DRF group had a greater incidence of NCD compared to the control group (11.3% vs. 8.2%) with a 56% greater relative risk (HR = 1.56, 95% Cl: 1.18, 2.07; p = 0.002) after adjusting for age and comorbidity. For every 10-year age increase, the DRF group was over three times more likely to develop a NCD (HR = 3.23, 95% Cl: 2.57, 4.04; p < 0.001).

Conclusion

DRF in adults ages 50 to 75 are associated with increased risk of developing neurocognitive disorders. DRF may represent a sentinel opportunity for cognitive screening and early intervention.

Summary

Distal radius fractures (DRF) have been associated with greater risk of future fractures and physical decline. This study reports that DRF are also associated with greater risk of developing neurocognitive disorders in older adults. Timely intervention may improve early recognition and long-term outcomes for older adults at risk of cognitive decline.

中文翻译：

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老年人桡骨远端骨折和发生神经认知障碍的风险：一项回顾性队列研究

介绍

桡骨远端骨折 (DRF) 与老年人后续骨折风险增加和身体衰退有关。本研究旨在评估 DRF 后认知能力下降的风险以及及时筛查和干预的潜力。

方法

在 1995 年至 2015 年期间确定了 1046 名 50-75 岁的 DRF 个体（81.5% 为女性；平均年龄 62.5 [± 7.1] 岁）。没有 DRF 病史的对照组（N  = 1044）与年龄、性别和骨折日期（即指数）相匹配。确定了与 DRF/指数相关的神经认知障碍 (NCD) 的发生率。组比较根据年龄和 Elixhauser 指数测量的合并症进行了调整。

结果

 与对照组相比，DRF 组的 NCD 发生率更高（11.3% 对 8.2%），在调整年龄后相对风险增加 56%（HR = 1.56, 95% Cl: 1.18, 2.07; p = 0.002）和合并症。年龄每增加 10 岁，DRF 组患 NCD 的可能性增加三倍以上（HR = 3.23, 95% Cl: 2.57, 4.04; p  < 0.001）。

结论

50 至 75 岁成年人的 DRF 与患神经认知障碍的风险增加有关。DRF 可能代表认知筛查和早期干预的前哨机会。

概括

桡骨远端骨折 (DRF) 与未来骨折和身体衰退的更大风险有关。该研究报告称，DRF 还与老年人患神经认知障碍的风险增加有关。及时干预可能会改善有认知能力下降风险的老年人的早期识别和长期结果。