The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer, but is also involved in normal physiological processes in adults. The canonical Wnt signaling pathway regulates cell pluripotency and determines the differentiation fate of cells during development. The canonical Wnt signaling pathway (also known as the Wnt/β-catenin signaling pathway) is a recognized driver of colon cancer and one of the most representative signaling pathways. As a functional effector molecule of Wnt signaling, the modification and degradation of β-catenin are key events in the Wnt signaling pathway and the development and progression of colon cancer. Therefore, the Wnt signaling pathway plays an important role in the pathogenesis of diseases, especially the pathogenesis of colorectal cancer (CRC). Inhibit the Wnt signaling pathway to explore the therapeutic targets of colorectal cancer. Based on studying the Wnt pathway, master the biochemical processes related to the Wnt pathway, and analyze the relevant targets when drugs or inhibitors act on the Wnt pathway, to clarify the medication ideas of drugs or inhibitors for the treatment of diseases, especially colorectal cancer. Wnt signaling pathways include: Wnt/β-catenin or canonical Wnt signaling pathway, planar cell polarity (Wnt-PCP) pathway and Wnt-Ca2+ signaling pathway. The Wnt signaling pathway is closely related to cancer cell proliferation, stemness, apoptosis, autophagy, metabolism, inflammation and immunization, microenvironment, resistance, ion channel, heterogeneity, EMT/migration/invasion/metastasis. Drugs/phytochemicals and molecular preparations for the Wnt pathway of CRC treatment have now been developed. Wnt inhibitors are also commonly used clinically for the treatment of CRC. The development of drugs/phytochemicals and molecular inhibitors targeting the Wnt pathway can effectively treat colorectal cancer clinically.

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结直肠癌中的 Wnt 信号传导：致病作用和治疗靶点

Wnt 信号通路是一个复杂的蛋白质相互作用网络，在胚胎发育和癌症中最常见，但也参与成人的正常生理过程。经典的 Wnt 信号通路调节细胞多能性并决定细胞在发育过程中的分化命运。经典的 Wnt 信号通路（也称为 Wnt/β-catenin 信号通路）是公认的结肠癌驱动因素，也是最具代表性的信号通路之一。作为Wnt信号通路的功能性效应分子，β-catenin的修饰和降解是Wnt信号通路和结肠癌发生发展的关键事件。因此，Wnt信号通路在疾病的发病机制中发挥着重要作用，尤其是结直肠癌（CRC）的发病机制。抑制Wnt信号通路，探索结直肠癌的治疗靶点。在研究Wnt通路的基础上，掌握Wnt通路相关的生化过程，分析药物或抑制剂作用于Wnt通路时的相关靶点，阐明药物或抑制剂治疗疾病特别是结直肠癌的用药思路. Wnt信号通路包括：Wnt/β-catenin或经典Wnt信号通路、平面细胞极性(Wnt-PCP)通路和Wnt-Ca2+信号通路。Wnt信号通路与癌细胞增殖、干性、凋亡、自噬、代谢、炎症和免疫、微环境、耐药性、离子通道、异质性、EMT/迁移/侵袭/转移等密切相关。现已开发出用于治疗 CRC 的 Wnt 途径的药物/植物化学物质和分子制剂。Wnt抑制剂在临床上也常用于治疗CRC。靶向Wnt通路的药物/植物化学物质和分子抑制剂的开发可以在临床上有效治疗结直肠癌。