Patients with Parkinson’s disease (PD) were described less extraverted and more neurotic. It remained unclear whether similar personality traits could be found in idiopathic rapid eye movement sleep behavior disorder (iRBD), a prodromal stage of PD, and could predict phenoconversion to neurodegenerative disorders. We aimed to investigate the personality profile and its association with future neurodegenerative phenoconversion in iRBD patients. One hundred and eighty-five video-polysomnography confirmed iRBD patients and 91 age- and sex-matched controls underwent personality assessment using the NEO five-factor inventory, and 171 iRBD patients were followed up. Our results showed that iRBD was marginally negatively associated with extraverted personality trait (B = −0.28, 95% confidence interval (CI) = −0.55, −0.001). During a median follow-up of 5.9 years, 47 iRBD patients (27.5%) had phenoconversion. More neurotic (adjusted hazard ratio (HR) = 2.0, 95% CI = 1.3, 3.1) and less extraverted personality traits (adjusted HR = 0.53, 95% CI = 0.36, 0.77) were associated with an increased risk of phenoconversion in iRBD patients. Our findings suggest that personality profile may be a potential prodromal marker of iRBD.

帕金森病 (PD) 患者被描述为更少外向和更神经质。目前尚不清楚在特发性快速眼动睡眠行为障碍 (iRBD)（PD 的前驱阶段）中是否可以发现相似的人格特征，并且可以预测神经退行性疾病的表型转变。我们旨在调查 iRBD 患者的人格特征及其与未来神经退行性表型转换的关联。185 名视频多导睡眠图确认 iRBD 患者和 91 名年龄和性别匹配的对照者使用 NEO 五因素量表进行了人格评估，并对 171 名 iRBD 患者进行了随访。我们的研究结果表明，iRBD 与外向人格特质呈轻微负相关（B = -0.28, 95% 置信区间 (CI) = -0.55, -0.001）。在 5 的中位随访期间。9 年，47 名 iRBD 患者（27.5%）发生了表型转换。更神经质（调整后的风险比 (HR) = 2.0, 95% CI = 1.3, 3.1）和较少外向的人格特质（调整后的 HR = 0.53, 95% CI = 0.36, 0.77）与 iRBD 患者的表型转化风险增加相关. 我们的研究结果表明，性格特征可能是 iRBD 的潜在前驱标志物。