Background Dietary inflammation is associated with increased risk of frailty. Those with depressive symptoms may be at higher risk of frailty onset since they typically have higher levels of inflammation. The study objective was to determine the association between a pro-inflammatory diet and frailty onset in those with and without clinically relevant depressive symptoms. Methods This prospective study included 1,701 non-frail individuals with self-reported baseline (1998-2001) data available for the evaluation of energy-adjusted dietary inflammatory index (E-DII TM) (calculated from food frequency questionnaires), depressive symptoms (from the Center for Epidemiologic Studies Depression; CES-D), and follow-up frailty measurements (2011-2014). Frailty was defined as fulfilling ≥3 Fried frailty criteria. Results are presented by baseline CES-D scores <16 or ≥16 points, which denotes the absence or presence of clinically relevant depressive symptoms, respectively. Logistic regression estimated odds ratios (OR) and 95% confidence intervals (95% CI) between E-DII and frailty onset, adjusting for confounders. Results In all study participants, mean (standard deviation; SD) age was 58(8) years and E-DII was -1.95 (2.20; range: -6.71 to +5.40, higher scores denote a more pro-inflammatory diet), and 45% were male. In those without clinically relevant depressive symptoms, one-unit higher E-DII score was associated with 14% increased odds (95% CI :1.05-1.24) of frailty. In those with depressive symptoms, one-unit higher E-DII score was associated with 55% increased odds of frailty (95% CI: 1.13-2.13). Conclusions The association between inflammatory diet and increased odds of frailty appeared somewhat stronger among those with depressive symptoms. This preliminary finding warrants further investigation.

中文翻译：

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促炎饮食与有或没有抑郁症状的成年人虚弱发作的关系：弗雷明汉后代研究的结果

背景饮食炎症与虚弱风险增加相关。那些有抑郁症状的人可能面临更高的虚弱风险，因为他们通常有更高水平的炎症。该研究的目的是确定促炎饮食与有或没有临床相关抑郁症状的人虚弱发作之间的关联。方法 这项前瞻性研究纳入了 1,701 名非体弱个体，他们的自我报告基线（1998-2001 年）数据可用于评估能量调整饮食炎症指数 (E-DII TM)（根据食物频率调查问卷计算）、抑郁症状（根据抑郁症流行病学研究中心；CES-D），以及后续虚弱测量（2011-2014）。衰弱被定义为满足 ≥3 Fried 衰弱标准。结果通过基线CES-D评分＜16或≥16分来呈现，其分别表示不存在或存在临床相关抑郁症状。Logistic 回归估计 E-DII 和虚弱发作之间的比值比 (OR) 和 95% 置信区间 (95% CI)，并针对混杂因素进行调整。结果 在所有研究参与者中，平均（标准差；SD）年龄为 58(8) 岁，E-DII 为 -1.95（2.20；范围：-6.71 至 +5.40，分数越高表示促炎饮食越多），并且45%是男性。在那些没有临床相关抑郁症状的患者中，E-DII 评分每升高一个单位，虚弱的几率就会增加 14%（95% CI：1.05-1.24）。在有抑郁症状的患者中，E-DII 评分每升高一个单位，虚弱几率就会增加 55%（95% CI：1.13-2.13）。结论 在有抑郁症状的人中，炎症性饮食与虚弱几率增加之间的关联似乎更强。这一初步发现值得进一步调查。