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Node foretold: Cancer cells in lymph node rewire the immune system to enable further metastases
Cancer Cell ( IF 48.8 ) Pub Date : 2022-07-14 , DOI: 10.1016/j.ccell.2022.07.001 Hilda L Chan 1 , Xiang H-F Zhang 2
中文翻译:
节点预言:淋巴结中的癌细胞重新连接免疫系统以实现进一步转移
更新日期:2022-07-14
Cancer Cell ( IF 48.8 ) Pub Date : 2022-07-14 , DOI: 10.1016/j.ccell.2022.07.001 Hilda L Chan 1 , Xiang H-F Zhang 2
Affiliation
A Cell article reports that lymph node metastases can suppress the immune system, thereby promoting further cancer spread in mouse models; this is corroborated in patients as described in a letter in this issue of Cancer Cell. The lymph node thus actively generates a cancer-permissive environment and is an untapped target to manipulate the immune system.
中文翻译:
节点预言:淋巴结中的癌细胞重新连接免疫系统以实现进一步转移
一篇细胞文章报告说,淋巴结转移可以抑制免疫系统,从而促进小鼠模型中的癌症进一步扩散;正如本期癌症细胞中的一封信中所述,这在患者中得到了证实。因此,淋巴结积极地产生了一个允许癌症发生的环境,并且是一个尚未开发的操纵免疫系统的目标。