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Role of Mutations in Differential Recognition of Viral RNA Molecules by Peptides
Journal of Chemical Information and Modeling ( IF 5.6 ) Pub Date : 2022-07-14 , DOI: 10.1021/acs.jcim.2c00376
Amit Kumar 1 , Harish Vashisth 1
Affiliation  

The conserved noncoding RNA elements in viral genomes interact with proteins to regulate various events during viral replication. We report studies on the recognition mechanisms of two helical peptides, namely, a native (Rev) peptide and a lab-evolved (RSG1.2) peptide, by a highly conserved viral RNA element from the human immunodeficiency virus 1 genome. Specifically, we investigated the physical interactions between the viral RNA molecule and helical peptides by computing free energy changes on mutating key amino acid residues involved in recognition of an internal loop in the viral RNA molecule.

中文翻译:

突变在肽对病毒 RNA 分子的差异识别中的作用

病毒基因组中保守的非编码RNA元件与蛋白质相互作用,调节病毒复制过程中的各种事件。我们报告了人类免疫缺陷病毒 1 基因组中高度保守的病毒 RNA 元件对两种螺旋肽(即天然 (Rev) 肽和实验室进化 (RSG1.2) 肽)的识别机制的研究。具体来说,我们通过计算参与识别病毒RNA分子内环的关键氨基酸残基突变的自由能变化,研究了病毒RNA分子和螺旋肽之间的物理相互作用。
更新日期:2022-07-14
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