Broad-spectrum antibiotics should prevent disease, right? In this issue of Cell Host & Microbe, Drummond et al. turn logic on its head and show they actually drive more deadly invasive fungal-bacterial systemic co-infection. Prophylactic antibiotics increase susceptibility to these infections by targeting the commensal microbes required for gut-derived IL-17-mediated immunity.

中文翻译：

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长期接触抗生素后多米诺骨牌倒塌

广谱抗生素应该可以预防疾病，对吗？在本期《细胞宿主与微生物》中，Drummond 等人。颠覆逻辑并表明它们实际上导致了更致命的侵袭性真菌-细菌系统性双重感染。预防性抗生素通过针对肠道来源的 IL-17 介导的免疫所需的共生微生物来增加对这些感染的易感性。