Summary

Osteoporosis, the most common metabolic bone disease, leads to increased susceptibility to fractures. In 2020, about 150,000 osteoporotic fractures occurred in Iran. Osteoporosis and related fractures cost the community US$ 393 million.

Introduction

The present study aimed at estimating the economic burden of osteoporosis in Iran in 2020.

Methods

We estimated the annual economic burden of osteoporosis in the above 50 years old population using a prevalence-based approach and from a societal perspective. The incidence of osteoporosis and related fractures were estimated based on meta-analysis reports in Iran and international comparisons. The direct medical and non-medical costs as well as the monetary value of quality-adjusted life-years (QALYs) lost because of fractures were estimated. Cost data were extracted from patient records, medical services prices, and previous literature.

Results

A total of 154,530 osteoporotic fractures were estimated in Iran in 2020. The shares of the hip, vertebral, forearm, and other fractures were 14%, 15%, 17%, and 54%, respectively. There were also 3554 deaths from osteoporotic fractures. The economic burden of osteoporosis in Iran was estimated at US$ 393.24 million (US$ 2165 million purchasing power parity 2020). Direct medical and non-medical cost (47.44%), QALY loss (29.65%), and long-term care for prior hip fracture costs (9.4%) were the main component of the economic burden of osteoporosis.

Conclusion

The economic burdens of osteoporosis are significant in Iran. Interventions to prevent osteoporosis and especially associated fractures, such as screening and prophylaxis, can reduce the cost of the disease and improve patients’ quality of life. Further studies are needed to identify cost-effective and feasible interventions in Iran.

中文翻译：

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2020 年伊朗骨质疏松症的经济负担

概括

骨质疏松症是最常见的代谢性骨病，会导致骨折的易感性增加。2020年，伊朗发生了约15万例骨质疏松性骨折。骨质疏松症和相关骨折给社区造成了 3.93 亿美元的损失。

介绍

本研究旨在估计 2020 年伊朗骨质疏松症的经济负担。

方法

我们使用基于患病率的方法并从社会角度估计了 50 岁以上人群中骨质疏松症的年度经济负担。根据伊朗的荟萃分析报告和国际比较估计骨质疏松症和相关骨折的发生率。估计了因骨折而损失的直接医疗和非医疗成本以及质量调整生命年 (QALY) 的货币价值。成本数据是从患者记录、医疗服务价格和以前的文献中提取的。

结果

据估计，2020 年伊朗共有 154,530 例骨质疏松性骨折。髋部、脊椎、前臂和其他骨折的比例分别为 14%、15%、17% 和 54%。还有 3554 人死于骨质疏松性骨折。伊朗骨质疏松症的经济负担估计为 3.9324 亿美元（2020 年购买力平价为 21.65 亿美元）。直接医疗和非医疗成本（47.44%）、QALY损失（29.65%）和既往髋部骨折的长期护理成本（9.4%）是骨质疏松症经济负担的主要组成部分。

结论

骨质疏松症的经济负担在伊朗是巨大的。预防骨质疏松症特别是相关骨折的干预措施，例如筛查和预防，可以降低疾病成本并提高患者的生活质量。需要进一步研究以确定在伊朗具有成本效益和可行的干预措施。