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What Proportion of Patients With Musculoskeletal Tumors Demonstrate Thromboelastographic Markers of Hypercoagulability? A Pilot Study.
Clinical Orthopaedics and Related Research ( IF 4.2 ) Pub Date : 2022-07-12 , DOI: 10.1097/corr.0000000000002314
Samir Sabharwal 1 , Hulai B Jalloh , Adam S Levin , Carol D Morris
Affiliation  

Thromboelastography (TEG) is a point-of-care venipuncture test that measures the elasticity and strength of a clot formed from a patient's blood, providing a more comprehensive analysis of a patient's coagulation status than conventional measures of coagulation. TEG includes four primary markers: R-time, which measures the time to clot initiation and is a proxy for platelet function; K-value, which measures the time for said clot to reach an amplitude of 20 mm and is a proxy for fibrin cross-linking; maximum amplitude (MA), which measures the clot's maximum amplitude and is a proxy for platelet aggregation; and LY30, which measures the percentage of clot lysis 30 minutes after reaching the MA and is a proxy for fibrinolysis. Analysis of TEG-derived coagulation profiles may help surgeons identify patient-related and disease-related factors associated with hypercoagulability. TEG-derived coagulation profiles of patients with musculoskeletal oncology conditions have yet to be characterized.

中文翻译:


有多少比例的肌肉骨骼肿瘤患者表现出高凝状态的血栓弹力图标记?试点研究。



血栓弹力图 (TEG) 是一种即时静脉穿刺测试,可测量患者血液形成的凝块的弹性和强度,与传统凝血测量相比,可以更全面地分析患者的凝血状态。 TEG 包括四个主要标志物: R-时间,测量凝血起始时间,是血小板功能的代表; K值,测量所述凝块达到20毫米振幅的时间,是纤维蛋白交联的代表;最大幅度 (MA),测量血块的最大幅度,是血小板聚集的代表; LY30,测量达到 MA 后 30 分钟的凝块溶解百分比,是纤维蛋白溶解的代表。对 TEG 衍生的凝血曲线的分析可以帮助外科医生识别与高凝状态相关的患者相关和疾病相关因素。肌肉骨骼肿瘤患者的 TEG 凝血特征尚未确定。
更新日期:2022-07-12
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