The transition from psoriasis to psoriatic arthritis (PsA) occurs in 20–30% of patients; however, the mechanisms underlying the emergence of musculoskeletal disease are not well understood. Metabolic disease is prevalent in psoriasis patients, but whether metabolic factors, other than obesity, increase arthritis risk in psoriasis patients is not known. This study was undertaken to investigate the link between metabolic changes and disease progression in psoriasis patients.

中文翻译：

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通过血清代谢物的无偏分析揭示银屑病关节炎中胆汁酸、脂质和核苷酸的失调


20-30% 的患者会从银屑病转变为银屑病关节炎 (PsA)；然而，肌肉骨骼疾病出现的机制尚不清楚。代谢性疾病在银屑病患者中普遍存在，但除肥胖之外的代谢因素是否会增加银屑病患者的关节炎风险尚不清楚。本研究旨在调查牛皮癣患者代谢变化与疾病进展之间的联系。