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Both Disease Activity and HLA–B27 Status Are Associated With Gut Microbiome Dysbiosis in Spondyloarthritis Patients
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2022-07-11 , DOI: 10.1002/art.42289 Magali Berland 1 , Victoria Meslier 1 , Samar Berreira Ibraim 1 , Emmanuelle Le Chatelier 1 , Nicolas Pons 1 , Nicolas Maziers 1 , Florence Thirion 1 , Franck Gauthier 1 , Florian Plaza Oñate 1 , Jean-Pierre Furet 2 , Ariane Leboime 3 , Roula Said-Nahal 3 , Florence Levenez 1 , Nathalie Galleron 1 , Benoît Quinquis 1 , Philippe Langella 2 , Stanislav Dusko Ehrlich 4 , Maxime Breban 5
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2022-07-11 , DOI: 10.1002/art.42289 Magali Berland 1 , Victoria Meslier 1 , Samar Berreira Ibraim 1 , Emmanuelle Le Chatelier 1 , Nicolas Pons 1 , Nicolas Maziers 1 , Florence Thirion 1 , Franck Gauthier 1 , Florian Plaza Oñate 1 , Jean-Pierre Furet 2 , Ariane Leboime 3 , Roula Said-Nahal 3 , Florence Levenez 1 , Nathalie Galleron 1 , Benoît Quinquis 1 , Philippe Langella 2 , Stanislav Dusko Ehrlich 4 , Maxime Breban 5
Affiliation
Gut microbiome dysbiosis has previously been reported in spondyloarthritis (SpA) patients and could be critically involved in the pathogenesis of this disorder. The objectives of this study were to further characterize the microbiota structure in SpA patients and to investigate the relationship between dysbiosis and disease activity in light of the putative influence of the genetic background.
中文翻译：
疾病活动度和 HLA-B27 状态均与脊柱关节炎患者的肠道微生物群失调有关
此前曾在脊柱关节炎 (SpA) 患者中报道过肠道微生物群失调，并且可能与这种疾病的发病机制密切相关。本研究的目的是进一步表征 SpA 患者的微生物群结构，并根据遗传背景的推定影响研究菌群失调与疾病活动之间的关系。
更新日期：2022-07-11
中文翻译：
疾病活动度和 HLA-B27 状态均与脊柱关节炎患者的肠道微生物群失调有关
此前曾在脊柱关节炎 (SpA) 患者中报道过肠道微生物群失调，并且可能与这种疾病的发病机制密切相关。本研究的目的是进一步表征 SpA 患者的微生物群结构，并根据遗传背景的推定影响研究菌群失调与疾病活动之间的关系。
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