ABSTRACT

Objectives

This preliminary study aimed to establish the feasibility of running an adapted Mindfulness Based Cognitive Therapy (MBCT) intervention for people with mild dementia and depression. It also aimed to conduct an exploratory analysis as to whether the MBCT intervention would lead to greater improvements in measures of depression, anxiety, quality of life and cognition, as compared to treatment as usual (TAU).

Methods

A single-blind, multisite, feasibility randomized controlled trial was used. People with dementia and depression were recruited from participating memory services. Twenty participants were randomized to either an adapted MBCT and TAU group (n = 10) or TAU (n = 10). Measures of depression, anxiety, quality of life (QOL), and cognition were assessed at baseline and follow-up.

Results

The intervention was feasible in terms of high attendance and low levels of attrition. It was not judged feasible to recruit enough participants within the recruitment time-frame. The MBCT group did not show significant improvements in depression, anxiety, QOL, and cognition at follow-up, as compared to TAU.

Conclusion

There is currently inadequate evidence to recommend this adapted MBCT intervention for people with dementia for the treatment of depression within memory services. The MBCT intervention needs redevelopment and piloting before further testing in an RCT.

中文翻译：

---

正念干预治疗轻度痴呆症患者抑郁症的可行性：一项随机对照试验

摘要

目标

这项初步研究旨在确定对轻度痴呆症和抑郁症患者进行适应性正念认知疗法 (MBCT) 干预的可行性。它还旨在对 MBCT 干预与常规治疗 (TAU) 相比是否会导致抑郁、焦虑、生活质量和认知方面的措施有更大改善进行探索性分析。

方法

使用了单盲、多中心、可行性随机对照试验。患有痴呆症和抑郁症的人是从参与的记忆服务中招募的。20 名参与者被随机分配到适应性 MBCT 和 TAU 组 (n = 10) 或 TAU (n = 10)。在基线和随访时评估了抑郁、焦虑、生活质量 (QOL) 和认知的指标。

结果

就高出勤率和低流失率而言，干预是可行的。在招募时限内招募足够的参与者被认为是不可行的。与 TAU 相比，MBCT 组在后续的抑郁、焦虑、QOL 和认知方面没有显着改善。

结论

目前没有足够的证据推荐这种适应性 MBCT 干预用于痴呆症患者，以治疗记忆服务中的抑郁症。在 RCT 中进一步测试之前，MBCT 干预需要重新开发和试点。