Autonomic nerves innervate the lungs, but how these nerves guide lung development remains unclear. In this issue of Developmental Cell, Zhang et al. reveal that myofibroblasts and developing nerves cross-communicate through neurotrophins and neurotransmitters to drive alveologenesi—and that planar cell polarity signaling is critical to this process.

中文翻译：

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形成肺泡需要很多神经

自主神经支配肺部，但这些神经如何指导肺部发育仍不清楚。在本期《发育细胞》中，张等人。揭示了肌成纤维细胞和发育中的神经通过神经营养因子和神经递质进行交叉交流以驱动肺泡生成，而平面细胞极性信号传导对这一过程至关重要。